HCID 68557503, compound → HCID 68555950, compound

HRID 2036087Notes

Reaction equation

HRID 2036087 reaction equation
[O:1]=[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:5][C:4]2([CH2:17][CH2:16][CH2:15][N:14](C(OCC3C=CC=CC=3)=O)[CH2:13]2)[O:3]1>C(OCC)(=O)C.[OH-].[Pd+2].[OH-].[C]>[C:7]1([N:6]2[CH2:5][C:4]3([CH2:17][CH2:16][CH2:15][NH:14][CH2:13]3)[O:3][C:2]2=[O:1])[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 1

HCID 68557503HCID 68557503, compound

Product 1

HCID 68555950HCID 68555950, compoundYield 63.1%

Reagents, catalysts & solvents 2

HCID 178502593HCID 178502593, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of the above-mentioned crude benzyl 2-oxo-3-phenyl-1-oxa-3,7-diazaspiro[4.5]decane-7-carboxylate (2.0 g) in ethyl acetate (50 mL) was added 20% palladium hydroxide-carbon (200 mg), and the mixture was stirred at room temperature for 20 hr under a hydrogen atmosphere. The catalyst was filtered through celite, and the filtrate was evaporated under reduced pressure. The residue was washed with diisopropyl ether to give the object product (800 mg, 53%).

Workup

  1. filtrationThe catalyst was filtered through celite
  2. customthe filtrate was evaporated under reduced pressure
  3. washThe residue was washed with diisopropyl ether

Sources & evidence

ORD record
ord-7a55e61503814a8eae60e4654242b195
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

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