Potassium Carbonate → 1'-[6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazin-3-yl]-5H-spiro[furo[3,4-b]pyridine-7,4'-piperidine]

HRID 2036090Notes

Reaction equation

Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[S:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[CH:6][CH:7]=1.Cl.Cl.[NH:16]1[CH2:21][CH2:20][C:19]2([C:25]3=[N:26][CH:27]=[CH:28][CH:29]=[C:24]3[CH2:23][O:22]2)[CH2:18][CH2:17]1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:13][C:10]1[N:9]=[C:8]([C:5]2[N:4]=[N:3][C:2]([N:16]3[CH2:17][CH2:18][C:19]4([C:25]5=[N:26][CH:27]=[CH:28][CH:29]=[C:24]5[CH2:23][O:22]4)[CH2:20][CH2:21]3)=[CH:7][CH:6]=2)[S:12][N:11]=1

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 109218293-Chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazine

HCID 674371065H-spiro[furo[3,4-b]pyridine-7,4'-piperidine] dihydrochloride

Product 1

HCID 685560191'-[6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazin-3-yl]-5H-spiro[furo[3,4-b]pyridine-7,4'-piperidine]

Procedure

The object product (72 mg, 28%) was obtained in the same manner as in Example 1 and using 3-chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazine (150 mg), 5H-spiro[furo[3,4-b]pyridine-7,4′-piperidine] dihydrochloride (86 mg) and potassium carbonate (290 mg).

Sources & evidence

ORD record: ord-e2e1889d09a24c8e93145c5b5c6eabd8
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08575167B2

Reaction notes

Loading…