Potassium Carbonate → 1'-[6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazin-3-yl]spiro[indene-1,4'-piperidin]-3(2H)-one

HRID 2036095Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][C:4]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8](=[O:15])[CH2:7]2)[CH2:3][CH2:2]1.Cl[C:17]1[N:18]=[N:19][C:20]([C:23]2[S:27][N:26]=[C:25]([CH3:28])[N:24]=2)=[CH:21][CH:22]=1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:28][C:25]1[N:24]=[C:23]([C:20]2[N:19]=[N:18][C:17]([N:1]3[CH2:6][CH2:5][C:4]4([C:14]5[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=5)[C:8](=[O:15])[CH2:7]4)[CH2:3][CH2:2]3)=[CH:22][CH:21]=2)[S:27][N:26]=1

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 109218293-Chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazine

HCID 18467061spiro[indene-1,4'-piperidin]-3(2H)-one

Product 1

HCID 685557211'-[6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazin-3-yl]spiro[indene-1,4'-piperidin]-3(2H)-one

Procedure

The object product (106 mg, 40%) was obtained in the same manner as in Example 1 and using spiro[indene-1,4′-piperidin]-3(2H)-one (190 mg), 3-chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazine (150 mg) and potassium carbonate (150 mg).

Sources & evidence

ORD record: ord-4a29d58cf41a49ffa8e20f26885528b9
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08575167B2

Reaction notes

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