反应详情

温度

120 °C

3-Chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine (690 mg) obtained in Example 43(2), spiro[indole-3,3′-pyrrolidin]-2(1H)-one (800 mg), potassium carbonate (500 mg) and tetrabutylammonium iodide (130 mg) were suspended in N,N-dimethylformamide-tetrahydrofuran (1:1, v/v, 50 mL), and the suspension was stirred at 120° C. overnight. The mixture was cooled to room temperature, diluted with ethyl acetate, and washed with aqueous sodium carbonate solution. The organic layer was dried over sodium sulfate and the solvent was evaporated under reduced pressure. Ethyl acetate was added and the resulting precipitate was collected by filtration, and recrystallized from ethyl acetate to give the object product (750 mg, 62%).

1. temperatureThe mixture was cooled to room temperature
2. washwashed with aqueous sodium carbonate solution
3. dry with materialThe organic layer was dried over sodium sulfate
4. customthe solvent was evaporated under reduced pressure
5. additionEthyl acetate was added
6. filtrationthe resulting precipitate was collected by filtration
7. customrecrystallized from ethyl acetate