Potassium Carbonate → 8-[6-(3-Methyl-1,2,4-oxadiazol-5-yl)-3-pyridazinyl]-2-phenyl-2,8-diazaspiro[4.5]decan-3-one

HRID 2036127Notes

Reaction equation

HRID 2036127 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[CH:6][CH:7]=1.Cl.[C:15]1([N:21]2[C:25](=[O:26])[CH2:24][C:23]3([CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)[CH2:22]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:13][C:10]1[N:9]=[C:8]([C:5]2[N:4]=[N:3][C:2]([N:29]3[CH2:28][CH2:27][C:23]4([CH2:22][N:21]([C:15]5[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=5)[C:25](=[O:26])[CH2:24]4)[CH2:31][CH2:30]3)=[CH:7][CH:6]=2)[O:12][N:11]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 167322943-Chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazineHCID 68557471HCID 68557471, compound

Product 1

HCID 685552668-[6-(3-Methyl-1,2,4-oxadiazol-5-yl)-3-pyridazinyl]-2-phenyl-2,8-diazaspiro[4.5]decan-3-one

Procedure

The object product (142 mg, 64%) was obtained in the same manner as in Example 1 and using 3-chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine (111 mg) obtained in Example 43(2), 2-phenyl-2,8-diazaspiro[4.5]decan-3-one hydrochloride (150 mg) and potassium carbonate (155 mg).

Sources & evidence

ORD record
ord-676db6d26da94427b333523f0d206813
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

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