Potassium Carbonate → 1'-[6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazin-3-yl]-3H-spiro[1-benzofuran-2,4'-piperidin]-3-one

HRID 2036128Notes

Reaction equation

Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[CH:6][CH:7]=1.Cl.[NH:15]1[CH2:20][CH2:19][C:18]2([C:24](=[O:25])[C:23]3[CH:26]=[CH:27][CH:28]=[CH:29][C:22]=3[O:21]2)[CH2:17][CH2:16]1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:13][C:10]1[N:9]=[C:8]([C:5]2[N:4]=[N:3][C:2]([N:15]3[CH2:20][CH2:19][C:18]4([C:24](=[O:25])[C:23]5[CH:26]=[CH:27][CH:28]=[CH:29][C:22]=5[O:21]4)[CH2:17][CH2:16]3)=[CH:7][CH:6]=2)[O:12][N:11]=1

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 167322943-Chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine

HCID 685573603H-spiro[1-benzofuran-2,4'-piperidin]-3-one hydrochloride

Product 1

HCID 685557971'-[6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazin-3-yl]-3H-spiro[1-benzofuran-2,4'-piperidin]-3-one

Procedure

The object product (163 mg, 72%) was obtained in the same manner as in Example 1 and using 3-chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine (123 mg) obtained in Example 43(2), 3H-spiro[1-benzofuran-2,4′-piperidin]-3-one hydrochloride (150 mg) and potassium carbonate (173 mg).

Sources & evidence

ORD record: ord-c0c5da9aa0cb44cf8888390b0307c013
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08575167B2

Reaction notes

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