Potassium Carbonate → 3-(4-Benzoylpiperazine-1-yl)butane-2-one

HRID 2036182Notes

Reaction equation

HRID 2036182 reaction equation
[C:1]([N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl[CH:22]([CH3:26])[C:23](=[O:25])[CH3:24]>>[C:1]([N:9]1[CH2:14][CH2:13][N:12]([CH:22]([CH3:26])[C:23](=[O:25])[CH3:24])[CH2:11][CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 200263-Chloro-2-butanoneHCID 7626541-Benzoylpiperazine

Product 1

HCID 687460683-(4-Benzoylpiperazine-1-yl)butane-2-one

Procedure

0.05 g (73%) target compound as yellow syrup was yielded on the same method as manufacturing example 10 using 0.05 g (0.26 mmol) 1-benzoylpiperazine, 0.11 g (0.79 mmol, 3.0 eq.) potassium carbonate, 0.03 g (0.26 mmol, 1.0 eq.) 3-chloro-2-butanon.

Workup

  1. custom0.05 g (73%) target compound as yellow syrup was yielded on the same method

Sources & evidence

ORD record
ord-dd2bfa413f504195b33edebe74ad5ed6
Source dataset
uspto-grants-2013_11
Patent number
US08575173B2

Reaction notes

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