反应详情

The mixture of [1-(3-pyridin-2-yl-imidazo[1,2-b]pyridazin-2-yl)-ethyl]-carbamic acid benzyl ester (600 mg, 1.6 mmol) and dimethylsulfide (1.2 mL) in TFA (7.5 mL)) was stirred at rt overnight. The mixture was concentrated in vacuo. The residue was dissolved in EtOAc. The organic layer was washed with satd. sodium bicarbonate solution, dried over sodium sulfate, filtered and concentrated in vacuo to provide 1-(3-pyridin-2-yl-imidazo[1,2-b]pyridazin-2-yl)-ethylamine (450 mg): LC-MS (ESI) m/z 240.0 [M+H]+.

1. concentrationThe mixture was concentrated in vacuo
2. dissolutionThe residue was dissolved in EtOAc
3. washThe organic layer was washed with satd
4. dry with materialsodium bicarbonate solution, dried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated in vacuo