HCID 86656593, compound → HCID 44230391, compound

HRID 2036858Notes

Reaction equation

HRID 2036858 reaction equation
[CH3:1][NH:2][C:3]([N:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:15]([NH:17][O:18]C3CCCCO3)=[O:16])[CH:11]=2)[CH2:6]1)=[O:4]>CO.Cl>[OH:18][NH:17][C:15]([C:10]1[CH:11]=[C:12]2[C:7](=[CH:8][CH:9]=1)[CH2:6][N:5]([C:3]([NH:2][CH3:1])=[O:4])[CH2:14][CH2:13]2)=[O:16]

Participants

4

Reactant 1

HCID 86656593HCID 86656593, compound

Product 1

HCID 44230391HCID 44230391, compoundYield 103.3%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

A mixture of 110 mg N2-methyl-N6-(tetrahydro-2H-pyran-2-yloxy)-3,4-dihydroisoquinoline-2,6(1H)-dicarboxamide in 4 ml methanol and 6 ml 0.1M aqueous HCl is stirred for 16 h and evaporated. The residue is dissolved in acetonitrile and water and lyophilized. 85 mg of colorless foam are obtained. MH+=250.2

Workup

  1. customevaporated
  2. dissolutionThe residue is dissolved in acetonitrile

Sources & evidence

ORD record
ord-3913879ef882468aa02d59b5a571637d
Source dataset
uspto-grants-2013_11
Patent number
US08575193B2

Reaction notes

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