Hydrochloric Acid → HCID 44229350, compound

HRID 2036864Notes

Reaction equation

HRID 2036864 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][C:7]([N:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:19]([NH:21][O:22]C3CCCCO3)=[O:20])[CH:15]=2)[CH2:10]1)=[O:8].Cl>CO>[OH:22][NH:21][C:19]([C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[CH2:10][N:9]([C:7](=[O:8])[CH2:6][O:5][CH2:4][CH2:3][O:2][CH3:1])[CH2:18][CH2:17]2)=[O:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86656602HCID 86656602, compound

Product 1

HCID 44229350HCID 44229350, compoundYield 98.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 110 mg 2-[(2-methoxyethoxy)acetyl]-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide, 1 ml methanol and 1.5 ml 0.1N aqueous hydrochloric acid are stirred for 3 h at ambient temperature. Subsequently, the mixture is lyophilized. 85 mg of the title compound are obtained as colorless oil. MH+=309.1

Sources & evidence

ORD record
ord-a4a7633579134e8abfb1053b5772ee5e
Source dataset
uspto-grants-2013_11
Patent number
US08575193B2

Reaction notes

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