Hydrochloric Acid → HCID 44229351, compound

HRID 2036865Notes

Reaction equation

HRID 2036865 reaction equation
[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:14]([NH:16][O:17]C3CCCCO3)=[O:15])[CH:10]=2)[CH2:5]1)(=[O:3])[CH3:2].Cl>CO>[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:14]([NH:16][OH:17])=[O:15])[CH:10]=2)[CH2:5]1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86656603HCID 86656603, compound

Product 1

HCID 44229351HCID 44229351, compoundYield 36.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 150 mg of 2-acetyl-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide, 1 ml methanol and 1.5 ml of an aqueous, 0.1 N hydrochloric acid is stirred for 3 h at ambient temperature. The reaction mixture is lyophilized. 40 mg of the title compound are obtained as colorless oil. MH+=235.0

Sources & evidence

ORD record
ord-e6aa51618d304ac99a3d3cb397a84078
Source dataset
uspto-grants-2013_11
Patent number
US08575193B2

Reaction notes

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