Hydrochloric Acid → HCID 44229352, compound

HRID 2036866Notes

Reaction equation

HRID 2036866 reaction equation
[O:1]1[CH2:5][CH2:4][CH:3]([C:6]([N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:18]([NH:20][O:21]C4CCCCO4)=[O:19])[CH:14]=3)[CH2:9]2)=[O:7])[CH2:2]1.Cl>CO>[OH:21][NH:20][C:18]([C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[CH2:9][N:8]([C:6]([CH:3]1[CH2:4][CH2:5][O:1][CH2:2]1)=[O:7])[CH2:17][CH2:16]2)=[O:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86656604HCID 86656604, compound

Product 1

HCID 44229352HCID 44229352, compoundYield 102.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 176 mg of 2-(tetrahydrofuran-3-ylcarbonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide, 6 ml methanol and 6 ml of an aqueous, 0.1 N hydrochloric acid is stirred overnight at ambient temperature. The reaction mixture is evaporated and the residue is dissolved in a mixture of water and acetonitrile and lyophilized. 140 mg of the title compound are obtained as colorless solid. MH+=291.2

Workup

  1. customThe reaction mixture is evaporated
  2. dissolutionthe residue is dissolved in a mixture of water and acetonitrile

Sources & evidence

ORD record
ord-d3a85bf664bf4a549a95694369b22eb5
Source dataset
uspto-grants-2013_11
Patent number
US08575193B2

Reaction notes

Loading…