Hydrochloric Acid → HCID 44230397, compound

HRID 2036869Notes

Reaction equation

HRID 2036869 reaction equation
[CH:1]1([C:4]([N:6]2[CH2:15][CH2:14][C:13]3[C:8](=[CH:9][CH:10]=[C:11]([C:16]([NH:18][O:19]C4CCCCO4)=[O:17])[CH:12]=3)[CH2:7]2)=[O:5])[CH2:3][CH2:2]1.Cl>C(O)(C)C>[OH:19][NH:18][C:16]([C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[CH2:7][N:6]([C:4]([CH:1]1[CH2:3][CH2:2]1)=[O:5])[CH2:15][CH2:14]2)=[O:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86656605HCID 86656605, compound

Product 1

HCID 44230397HCID 44230397, compoundYield 148.9%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 80 mg of 2-(cyclopropylcarbonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide, 3 ml isopropanol and 3 ml of an aqueous, 0.1 N hydrochloric acid is stirred 4 h at ambient temperature. The reaction mixture is evaporated and the residue is dissolved in a mixture of 0.5 ml water and 0.5 ml acetonitrile and lyophilized. 90 mg of the title compound are obtained as solid with mp=90° C. MH+=261.1

Workup

  1. customThe reaction mixture is evaporated
  2. dissolutionthe residue is dissolved in a mixture of 0.5 ml water and 0.5 ml acetonitrile

Sources & evidence

ORD record
ord-eac39faf559544d1acf8d5424e7f1474
Source dataset
uspto-grants-2013_11
Patent number
US08575193B2

Reaction notes

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