Methanol → HCID 66881002, compound

HRID 2036886Notes

Reaction equation

HRID 2036886 reaction equation
[Na].[C:2]1(C)[C:3]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:5]=[CH:6][CH:7]=1.[CH3:13][O:14][C:15](=[O:26])[C:16]1[CH:21]=[CH:20][C:19]([CH2:22]Br)=[C:18]([CH2:24]Br)[CH:17]=1.[CH3:27]O>>[CH3:13][O:14][C:15]([C:16]1[CH:17]=[C:18]2[C:19](=[CH:20][CH:21]=1)[CH2:22][N:11]([S:8]([C:3]1[CH:2]=[CH:7][C:6]([CH3:27])=[CH:5][CH:4]=1)(=[O:9])=[O:10])[CH2:24]2)=[O:26]

Participants

5

Reactant 4

HCID 887MethanolHCID 69242-MethylbenzenesulfonamideHCID 2736819Methyl 3,4-bis(bromomethyl)benzoateHCID 5360545Sodium

Product 1

HCID 66881002HCID 66881002, compound

Procedure

Sodium (0.60 g) is dissolved in methanol (100 mL) and toluene sulfonamide (4.25 g) is added portion wise. After 30 min at ambient temperature 3,4-bis-bromomethyl-benzoic acid methyl ester are added (4.00 g). After stirring overnight, the resulting solid is collected, washed with methanol and dried. 2.80 g of the title compound are obtained with MP=164-166° C.

Workup

  1. customthe resulting solid is collected
  2. washwashed with methanol
  3. customdried

Sources & evidence

ORD record
ord-162c004f76cb4eeabf8982683195f918
Source dataset
uspto-grants-2013_11
Patent number
US08575193B2

Reaction notes

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