反应详情

温度

10 °C

Dissolve 2-(S)-(2-cyclohexylethyl)-5-(S)-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester (165 mg, 0.50 mmol) in dimethylsulfoxide (2 mL), and cool to 10° C. Add triethylamine (0.28 mL, 2.02 mmol) followed by pyridine sulfur trioxide complex and stir for 30 min. Dilute with ethyl acetate and pour into cold water. Wash with 5% citric acid (50 mL), saturated aqueous sodium chloride (50 mL) and dry (sodium sulfate), filter and concentrate give the desired compound as an oil which is used without further purification.

1. washWash with 5% citric acid (50 mL), saturated aqueous sodium chloride (50 mL)
2. dry with materialdry (sodium sulfate)
3. filtrationfilter
4. concentrationconcentrate