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HRID2037098

反应详情

EQUATION

反应方程式

HRID 2037098 反应方程式

REACTANTS

反应物

4
Diisopropylethylamine 分子结构式
HCID81531

Diisopropylethylamine

C8H19N

4-Morpholinopiperidine 分子结构式
HCID795724

4-Morpholinopiperidine

C9H18N2O

Methanaminium, N-[(1H-benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methyl-, hexafluorophosphate(1-) (1:1) 分子结构式
HCID2733084

Methanaminium, N-[(1H-benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methyl-, hexafluorophosphate(1-) (1:1)

C11H16F6N5OP

4-(3-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)benzoic acid 分子结构式
HCID44516307

4-(3-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)benzoic acid

C25H27N7O5

PRODUCTS

产物

1
HCID 44516633 分子结构式
HCID44516633

未命名化合物

收率 62%

AUXILIARIES

试剂、催化剂与溶剂

1
N-Methyl-2-pyrrolidone 分子结构式
溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

PROCEDURE

实验过程

To the stirred solution of 4-(3-(4-(4,6-dimorpholino-1,3,5-triazin-2yl)phenyl)ureido)benzoic acid (50 mg; 0.099 mmol), Hunig's base (103 μL, 0.594 mmol), HBTU (188 mg, 0.495 mmol) in 1 mL of NMP was reacted according to example 68 with 4-(piperidin-4-yl)morpholine (67 mg, 0.396 mmol). Evaporated the solvent and purified by HPLC to give the product (40.1 mg, 62% yield); MS (ESI) m/z=658.7

WORKUP

后处理

  1. customEvaporated the solvent
  2. custompurified by HPLC