Dimethylformamide → methyl 5-(4-chlorophenyl)-6-cyclohexyl-4-(2-morpholin-4-yl-2-oxoethyl)-4H-thieno[3,2-b]pyrrole-2-carboxylate

HRID 203723Notes

Reaction equation

HRID 203723 reaction equation
[CH2:30]1[CH2:31][O:32][CH2:33][CH2:34][NH:35]1.[CH:36]([N:37]([CH2:38][CH3:39])[CH:40]([CH3:41])[CH3:42])([CH3:43])[CH3:44].[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([CH:24]3[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]3)[c:10]3[c:11]([n:12]2[CH2:13][C:14](=[O:15])[OH:16])[cH:17][c:18]([C:20](=[O:21])[O:22][CH3:23])[s:19]3)[cH:6][cH:7]1.[Cl:74][CH2:75][Cl:76].[O:69]=[CH:70][N:71]([CH3:72])[CH3:73].[P-:45]([F:46])([F:47])([F:48])([F:49])([F:50])[F:51].[n:52]1([O:53][C:54]([N:55]([CH3:56])[CH3:57])=[N+:58]([CH3:59])[CH3:60])[c:61]2[n:62][cH:63][cH:64][cH:65][c:66]2[n:67][n:68]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([CH:24]3[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]3)[c:10]3[c:11]([n:12]2[CH2:13][C:14](=[O:15])[N:35]2[CH2:30][CH2:31][O:32][CH2:33][CH2:34]2)[cH:17][c:18]([C:20](=[O:21])[O:22][CH3:23])[s:19]3)[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8083MorpholineHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 68472059[5-(4-chlorophenyl)-6-cyclohexyl-2-(methoxycarbonyl)-4H-thieno[3,2-b]pyrrol-4-yl]acetic acid

Product 1

HCID 11432036methyl 5-(4-chlorophenyl)-6-cyclohexyl-4-(2-morpholin-4-yl-2-oxoethyl)-4H-thieno[3,2-b]pyrrole-2-carboxylate

Sources & evidence

ORD record
ord-a3337fe8625a4c87843d8b90ef4b2c6a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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