6-(1-Ethyl-propyl)-4-methoxy-pyridine-2-carboxylic acid methyl ester → 6-(1-Ethyl-propyl)-4-methoxy-pyridine-2-carboxylic acid

HRID 2037320Notes

Reaction equation

HRID 2037320 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[C:7]([CH:13]([CH2:16][CH3:17])[CH2:14][CH3:15])[N:6]=1)=[O:4]>Cl>[CH2:14]([CH:13]([C:7]1[N:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=1)[CH2:16][CH3:17])[CH3:15]

Participants

3

Reactant 1

HCID 686308886-(1-Ethyl-propyl)-4-methoxy-pyridine-2-carboxylic acid methyl ester

Product 1

HCID 686309506-(1-Ethyl-propyl)-4-methoxy-pyridine-2-carboxylic acidYield 139.6%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 6-(1-ethyl-propyl)-4-methoxy-pyridine-2-carboxylic acid methyl ester (450 mg, 1.90 mmol) in 25% aq. HCl is stirred at 65° C. for 18 h. The mixture is concentrated and dried to give the title compound (592 mg) as hydrochloride salt; LC-MS**: tR=0.38 min; [M+1]+=224.32.

Workup

  1. concentrationThe mixture is concentrated
  2. customdried

Sources & evidence

ORD record
ord-b45eb47f81dd4c3fbb5b8ab653b4bb6c
Source dataset
uspto-grants-2013_11
Patent number
US08575200B2

Reaction notes

Loading…