Trifluoroacetic acid → HCID 59626078, compound

HRID 2038418Notes

Reaction equation

HRID 2038418 reaction equation
[F:1][C:2]([F:30])([F:29])[C:3]1[CH:4]=[C:5]([C:9]2[C:17]3[C:12](=[CH:13][C:14]([C:18]([O:20][CH3:21])=[O:19])=[CH:15][CH:16]=3)[N:11](C(OC(C)(C)C)=O)[CH:10]=2)[CH:6]=[CH:7][CH:8]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[F:29][C:2]([F:1])([F:30])[C:3]1[CH:4]=[C:5]([C:9]2[C:17]3[C:12](=[CH:13][C:14]([C:18]([O:20][CH3:21])=[O:19])=[CH:15][CH:16]=3)[NH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59626050HCID 59626050, compound

Product 1

HCID 59626078HCID 59626078, compoundYield 122.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of compound 15c (900 mg, 2.14 mmol) in CH2Cl2 (5 mL) was added trifluoroacetic acid (2 mL) at room temperature. The mixture was stirred at room temperature for 2 h. The resulting mixture was concentrated to give compound 15d (840 mg) as a white solid. MS m/z (M+H+) 320.0.

Workup

  1. concentrationThe resulting mixture was concentrated

Sources & evidence

ORD record
ord-aff1011912644e2ba6faf733f062e415
Source dataset
uspto-grants-2013_11
Patent number
US08575363B2

Reaction notes

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