Hydrochloric Acid → Benzenepropanol, 3-(trifluoromethyl)-

Temperature

2.5 °C

Compound obtained from Example 1 (0.463 moles, 100 gms) was suspended in 500 ml of tetrahydrofuran under stirring. The reaction mass was cooled to 0-5° C. 94% solution of borane dimethyl sulfide solution (0.62 moles, 50 ml) was added drop wise maintaining the temperature of 0-5° C. The reaction mass was stirred at 25-30° C. for about 10 hours. 10% HCl (100 ml) was added drop wise to the reaction mass at 25-30° C. in about 2 hours and then extracted with toluene (2×250 ml). The organic layer was separated and washed with water (5×500 ml). Toluene was removed completely from the organic layer by distillation under vacuum to isolate the title compound as an oil (85 gms, Yield 90%).

1. temperaturewise maintaining the temperature of 0-5° C
2. stirringThe reaction mass was stirred at 25-30° C. for about 10 hours
3. extractionextracted with toluene (2×250 ml)
4. customThe organic layer was separated
5. washwashed with water (5×500 ml)
6. customToluene was removed completely from the organic layer by distillation under vacuum

ORD record

ord-094bd6517a2148698a354c551e32c8b7

Source dataset

uspto-grants-2013_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08575393B2