Hydrochloric Acid → HCID 68378932, compound

HRID 2038748Notes

Reaction equation

HRID 2038748 reaction equation
C(OC(=O)[NH:7][C:8]1([C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[CH:19][C:20]4[N:21]([CH:23]=[C:24]([CH3:26])[N:25]=4)[CH:22]=3)=[CH:13][N:12]=2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:28]>C(Cl)Cl.O1CCOCC1>[ClH:28].[ClH:28].[CH3:26][C:24]1[N:25]=[C:20]2[CH:19]=[CH:18][C:17]([C:14]3[CH:15]=[CH:16][C:11]([C:8]4([NH2:7])[CH2:9][CH2:10]4)=[N:12][CH:13]=3)=[CH:22][N:21]2[CH:23]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67508138HCID 67508138, compound

Product 1

HCID 68378932HCID 68378932, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

{1-[5-(2-Methyl-imidazo[1,2-a]pyridin-6-yl)-pyridin-2-yl]-cyclopropyl}-carbamic acid tert-butyl ester (21 mg, 0.06 mmol) was dissolved in 0.5 mL of CH2Cl2 and 1 mL of 4M HCl in dioxane was added. The resulting suspension was stirred for 1 h. The mixture was concentrated to yield crude 1-[5-(2-methyl-imidazo[1,2-a]pyridin-6-yl)-pyridin-2-yl]-cyclopropylamine dihydrochloride. The material was used in subsequent reactions without purification.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-76b627fd0a3c4ed9a29f5ddb04f935c3
Source dataset
uspto-grants-2013_11
Patent number
US08575360B2

Reaction notes

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