Carbon tetrabromide → HCID 57197627, compound

3-(4-Propylphenyl)propanol (s3) (11.0 g) and triphenylphosphine (24.3 g) were dissolved in methylene chloride (200 ml). Carbon tetrabromide (24.5 g) in methylene chloride (100 ml) solution was slowly added dropwise to the solution, and the mixture was stirred at room temperature for another 3 hours. The reaction mixture was treated with a saturated aqueous solution of sodium hydrogencarbonate, and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed successively with water and brine, and dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure to leave a residue, pale yellow solids. The residue was purified by column chromatography with heptane as an eluent and silica gel as a stationary phase powder to give 3-(4-propylphenyl)bromopropane (s4) (14.5 g). The yield based on the compound (s3) was 97.4%.

1. extractionthe aqueous layer was extracted with ethyl acetate
2. washThe combined organic layers were washed successively with water and brine
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationThe solution was concentrated under reduced pressure
5. customto leave a residue, pale yellow solids
6. customThe residue was purified by column chromatography with heptane as an eluent

ORD record

ord-bef5b61bb9894cdcb3b3f36c0cb7cd40

Source dataset

uspto-grants-2013_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08580146B2