反应详情

2-(3-(dibenzo[b,d]thiophen-4-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (8.80 g, 22.78 mmol) and 1,3-dibromobenzene (21.49 g, 91 mmol) were dissolved in toluene (300 mL), and potassium carbonate (9.44 g, 68.3 mmol) in 50 mL of water and the Pd(PPh3)4 catalyst (0.263 g, 0.228 mmol) were then added. The reaction mixture was degassed and refluxed under N2 overnight. The organic layer was then separated, evaporated and subjected to column chromatography on silica gel, eluted with hexane/DCM 9:1 v/v mixture, providing 4-(3′-bromo-[1,1′-biphenyl]-3-yl)dibenzo[b,d]thiophene (7.5 g, 18.06 mmol, 79% yield) as white solid.

1. customThe reaction mixture was degassed
2. temperaturerefluxed under N2 overnight
3. customThe organic layer was then separated
4. customevaporated
5. washeluted with hexane/DCM 9:1 v/v mixture