Hydrochloric Acid → HCID 59484923, compound

HRID 2039589Notes

Reaction equation

HRID 2039589 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10](=[O:13])[N:9]([CH2:14][C:15]3[CH:16]=[C:17]([C:21]4[N:26]=[CH:25][C:24]([N:27]5CCN(C(OC(C)(C)C)=O)CC5)=[CH:23][N:22]=4)[CH:18]=[CH:19][CH:20]=3)[N:8]=2)[CH:4]=[N:3]1.Cl>O1CCOCC1>[NH2:27][C:24]1[CH:23]=[N:22][C:21]([C:17]2[CH:16]=[C:15]([CH:20]=[CH:19][CH:18]=2)[CH2:14][N:9]2[C:10](=[O:13])[CH:11]=[CH:12][C:7]([C:5]3[CH:4]=[N:3][N:2]([CH3:1])[CH:6]=3)=[N:8]2)=[N:26][CH:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59484912HCID 59484912, compound

Product 1

HCID 59484923HCID 59484923, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

90 mg (0.17 mmol) of tert-butyl 4-(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yl)piperazine-1-carboxylate are dissolved in 10 ml of dioxane, and 1 ml of 4 N HCl in dioxane is added. The reaction mixture is stirred at room temperature for 15 h and subsequently evaporated to dryness; yield: 80 mg of “A292” hydrochloride; HPLC: 2.05 min (method C); LC-MS: 429 (M+H).

Workup

  1. customsubsequently evaporated to dryness
  2. custom2.05 min (method C)

Sources & evidence

ORD record
ord-e3476dc729984d05aa182dfa7e7380df
Source dataset
uspto-grants-2013_11
Patent number
US08580781B2

Reaction notes

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