Cyclopropanemethanamine → HCID 57855949, compound

HRID 2039603Notes

Reaction equation

HRID 2039603 reaction equation
[Cl:1][C:2]1[C:3]2[C:8]([CH:9]=[C:10]3[C:15]=1[N:14]=[C:13]([C:16]1[N:17]([C:25]4[C:30]([Cl:31])=[CH:29][CH:28]=[CH:27][N:26]=4)[N:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=1)[O:12][C:11]3=[O:32])=[N:7][CH:6]=[CH:5][N:4]=2.[CH:33]1([CH2:36][NH2:37])[CH2:35][CH2:34]1>C1COCC1>[CH:33]1([CH2:36][NH:37][C:11]([C:10]2[CH:9]=[C:8]3[C:3](=[C:2]([Cl:1])[C:15]=2[NH:14][C:13]([C:16]2[N:17]([C:25]4[C:30]([Cl:31])=[CH:29][CH:28]=[CH:27][N:26]=4)[N:18]=[C:19]([C:21]([F:23])([F:24])[F:22])[CH:20]=2)=[O:12])[N:4]=[CH:5][CH:6]=[N:7]3)=[O:32])[CH2:35][CH2:34]1

Participants

4

Reactant 2

HCID 75646CyclopropanemethanamineHCID 57855896HCID 57855896, compound

Product 1

HCID 57855949HCID 57855949, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.55 g (1.15 mol) 9-chloro-2-[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-3-oxa-1,5,8-triaza-anthracen-4-one and 0.5 ml C-cyclopropylmethylamine is dissolved in 15 ml THF and stirred for 8 hours. After evaporation, the residue is crystallised in diethyl ether to give 0.47 g (74%) of the title compound. m.p.: 180-183° C.

Workup

  1. customAfter evaporation
  2. customthe residue is crystallised in diethyl ether

Sources & evidence

ORD record
ord-a1e971d9561c4b428b2b732cb225479f
Source dataset
uspto-grants-2013_11
Patent number
US08580785B2

Reaction notes

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