Methylamine → HCID 57855921, compound

HRID 2039613Notes

Reaction equation

HRID 2039613 reaction equation
[Cl:1][C:2]1[C:3]2[C:8]([CH:9]=[C:10]3[C:15]=1[N:14]=[C:13]([C:16]1[N:17]([C:25]4[C:30]([Cl:31])=[CH:29][CH:28]=[CH:27][N:26]=4)[N:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=1)[O:12][C:11]3=[O:32])=[N:7][C:6]([CH3:33])=[C:5]([CH3:34])[N:4]=2.[CH3:35][NH2:36]>>[CH3:35][NH:36][C:11]([C:10]1[CH:9]=[C:8]2[C:3](=[C:2]([Cl:1])[C:15]=1[NH:14][C:13]([C:16]1[N:17]([C:25]3[C:30]([Cl:31])=[CH:29][CH:28]=[CH:27][N:26]=3)[N:18]=[C:19]([C:21]([F:22])([F:23])[F:24])[CH:20]=1)=[O:12])[N:4]=[C:5]([CH3:34])[C:6]([CH3:33])=[N:7]2)=[O:32]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 57856003HCID 57856003, compound

Product 1

HCID 57855921HCID 57855921, compoundYield 68%

Procedure

See example H3 for the reaction conditions using 9-chloro-2-[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-6,7-dimethyl-3-oxa-1,5,8-triaza-anthracen-4-one as starting material and 2 equivalents of methylamine (40% in H2O). After 10 hours reaction time and purification by flash chromatography on silica gel, a white solid is obtained in 68% yield. m.p.: 221-224° C.

Workup

  1. customH3 for the reaction conditions
  2. customAfter 10 hours reaction time and purification by flash chromatography on silica gel
  3. customa white solid is obtained in 68% yield

Sources & evidence

ORD record
ord-422e243aae974e2aac068af52d60a079
Source dataset
uspto-grants-2013_11
Patent number
US08580785B2

Reaction notes

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