Methylamine → HCID 57855911, compound

HRID 2039623Notes

Reaction equation

[Cl:1][C:2]1[C:11]2[N:10]=[C:9]([C:12]3[N:13]([C:21]4[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][N:22]=4)[N:14]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:16]=3)[O:8][C:7](=[O:28])[C:6]=2[CH:5]=[C:4]2[NH:29][CH:30]=[N:31][C:3]=12.[CH3:32][NH2:33]>>[CH3:32][NH:33][C:7]([C:6]1[C:11]([NH:10][C:9]([C:12]2[N:13]([C:21]3[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][N:22]=3)[N:14]=[C:15]([C:17]([F:18])([F:20])[F:19])[CH:16]=2)=[O:8])=[C:2]([Cl:1])[C:3]2[N:31]=[CH:30][NH:29][C:4]=2[CH:5]=1)=[O:28]

Participants

Reactant 2

HCID 6329Methylamine

HCID 136174558HCID 136174558, compound

Product 1

HCID 57855911HCID 57855911, compoundYield 26%

Procedure

See example H3 using 4-chloro-6-[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-1H-7-oxa-1,3,5-triaza-cyclopenta[b]naphthalen-8-one as starting material and 3 equivalents of methylamine (40% in H2O). A white solid is obtained within 26% yield. m.p.: 190-192° C.; LC/MS: 498/500 (M+1)+.

Workup

customA white solid is obtained within 26% yield

Sources & evidence

ORD record: ord-3b95f614844d484f90a32dedaf3f6e54
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08580785B2

Reaction notes

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