Methylamine → HCID 57855914, compound

HRID 2039642Notes

Reaction equation

HRID 2039642 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:14]2[O:27][C:26](=[O:28])[C:25]3[C:16](=[CH:17][C:18]4[C:23]([CH:24]=3)=[N:22][C:21]([C:29]([F:32])([F:31])[F:30])=[CH:20][CH:19]=4)[N:15]=2)[N:5]([C:7]2[C:12]([Cl:13])=[CH:11][CH:10]=[CH:9][N:8]=2)[N:6]=1.[CH3:33][NH2:34]>C1COCC1>[CH3:33][NH:34][C:26]([C:25]1[CH:24]=[C:23]2[C:18]([CH:19]=[CH:20][C:21]([C:29]([F:32])([F:31])[F:30])=[N:22]2)=[CH:17][C:16]=1[NH:15][C:14]([C:4]1[N:5]([C:7]2[C:12]([Cl:13])=[CH:11][CH:10]=[CH:9][N:8]=2)[N:6]=[C:2]([Br:1])[CH:3]=1)=[O:27])=[O:28]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 57855895HCID 57855895, compound

Product 1

HCID 57855914HCID 57855914, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-[5-Bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazol-3-yl]-6-trifluoromethyl-3-oxa-1,5-diaza-anthracen-4-one is reacted with methylamine in THF analogously to the procedure given in step i) of example H-18. The title product is obtained as pale yellow crystals after flash column chromatography. LC/MS: 553/555/557 (M+1)+; m.p.: 127-129° C.

Sources & evidence

ORD record
ord-f1f6ff7e02b24e98a65f9d854da0742a
Source dataset
uspto-grants-2013_11
Patent number
US08580785B2

Reaction notes

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