Methylamine → HCID 57855950, compound

HRID 2039647Notes

Reaction equation

HRID 2039647 reaction equation
[Cl:1][C:2]1[C:3]([N:8]2[C:12]([C:13]3[O:26][C:25](=[O:27])[C:24]4[C:15](=[C:16]([O:32][CH3:33])[C:17]5[C:22]([CH:23]=4)=[N:21][C:20]([C:28]([F:31])([F:30])[F:29])=[CH:19][CH:18]=5)[N:14]=3)=[CH:11][C:10]([C:34]([F:37])([F:36])[F:35])=[N:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.[CH3:38][NH2:39]>C1COCC1>[CH3:38][NH:39][C:25]([C:24]1[CH:23]=[C:22]2[C:17]([CH:18]=[CH:19][C:20]([C:28]([F:29])([F:30])[F:31])=[N:21]2)=[C:16]([O:32][CH3:33])[C:15]=1[NH:14][C:13]([C:12]1[N:8]([C:3]2[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][N:4]=2)[N:9]=[C:10]([C:34]([F:35])([F:37])[F:36])[CH:11]=1)=[O:26])=[O:27]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 57855929HCID 57855929, compound

Product 1

HCID 57855950HCID 57855950, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-[2-(3-Chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-9-methoxy-6-trifluoromethyl-3-oxa-1,5-diaza-anthracen-4-one is reacted with methylamine in THF analogously to the procedure given in step i) of example H-18. The title product is obtained as yellow crystals after flash column chromatography eluting with 1:1 hexane:ethyl acetate. m.p.: 209-211° C.

Sources & evidence

ORD record
ord-d3ec0564981a4bfebd5cbd512ecf7702
Source dataset
uspto-grants-2013_11
Patent number
US08580785B2

Reaction notes

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