Hydrochloric Acid → HCID 86651085, compound

HRID 2039844Notes

Reaction equation

HRID 2039844 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[C:20]([Cl:25])[N:21]=[CH:22][CH:23]=3)[N:18]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:17]=2[CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[C:35]([F:39])[C:34]=2[CH3:40])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.Cl.Cl.ClC1N=CC=C2C(C(N3CCNCC3)=O)=C(CC3C=CC=C(F)C=3C)N(C3C=CC=CC=3)C=12>>[Cl:25][C:20]1[N:21]=[CH:22][CH:23]=[C:24]2[C:16]([C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[O:15])=[C:17]([CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[C:35]([F:39])[C:34]=3[CH3:40])[N:18]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:19]=12

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 86651086HCID 86651086, compoundHCID 87206065HCID 87206065, compound

Product 1

HCID 86651085HCID 86651085, compoundYield 35.1%

Procedure

The compound of step 1 (30 mg, 53 μmol) was reacted analogously as described in example 4, step 2. Dissolution of the obtained solid in a small quantity of MOH, addition of hydrochloric acid (0.1 M) and lyophilization overnight yielded 8.6 mg of the title compound in the form of the [7-chloro-2-(3-fluoro-2-methyl-benzyl)-1-phenyl-1H-pyrrolo[2,3-c]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

Workup

  1. dissolutionDissolution of the obtained solid

Sources & evidence

ORD record
ord-99c4bd97401f4948b03ae47d79014ae7
Source dataset
uspto-grants-2013_11
Patent number
US08580813B2

Reaction notes

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