Hydrochloric Acid → HCID 56678527, compound

HRID 2039845Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[C:20]([CH2:25][C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[C:27]=4[CH3:33])[N:21]=[CH:22][CH:23]=3)[N:18]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[C:17]=2[CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[C:43]([F:47])[C:42]=2[CH3:48])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.Cl.Cl.FC1C(C)=C(C=CC=1)CC1N(C2C=CC=CC=2)C2=C(CC3C=CC=C(F)C=3C)N=CC=C2C=1C(N1CCNCC1)=O>>[F:47][C:43]1[C:42]([CH3:48])=[C:41]([CH:46]=[CH:45][CH:44]=1)[CH2:40][C:17]1[N:18]([C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)[C:19]2=[C:20]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[C:27]=3[CH3:33])[N:21]=[CH:22][CH:23]=[C:24]2[C:16]=1[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:15]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 66922273HCID 66922273, compound

HCID 66922280HCID 66922280, compound

Product 1

HCID 56678527HCID 56678527, compoundYield 89.3%

Procedure

The compound of step 1 (40 mg, 61 μmol) was reacted analogously as described in example 4, step 2. Dissolution of the obtained solid in a small quantity of MOH, addition of hydrochloric acid (0.1 M) and lyophilization overnight yielded 30 mg of the title compound in the form of the [2,7-bis-(3-fluoro-2-methyl-benzyl)-1-phenyl-1H-pyrrolo[2,3-c]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

Workup

dissolutionDissolution of the obtained solid

Sources & evidence

ORD record: ord-65a57e9571fa467585109c858cf78398
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08580813B2

Reaction notes

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