Hydrochloric Acid → HCID 56671819, compound

HRID 2039848Notes

Reaction equation

HRID 2039848 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[C:20]([CH2:25][CH3:26])[N:21]=[CH:22][CH:23]=3)[N:18]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:17]=2[O:33][C:34]2[CH:39]=[C:38]([F:40])[CH:37]=[CH:36][C:35]=2[CH3:41])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.Cl.Cl.C(C1N=CC=C2C(C(N3CCNCC3)=O)=C(OC3C=C(F)C=CC=3C)N(C3C=CC=CC=3)C=12)C>>[CH2:25]([C:20]1[N:21]=[CH:22][CH:23]=[C:24]2[C:16]([C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[O:15])=[C:17]([O:33][C:34]3[CH:39]=[C:38]([F:40])[CH:37]=[CH:36][C:35]=3[CH3:41])[N:18]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:19]=12)[CH3:26]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 66922268HCID 66922268, compoundHCID 66922282HCID 66922282, compound

Product 1

HCID 56671819HCID 56671819, compoundYield 50.3%

Procedure

The compound of step 1 (29 mg, 52 μmol) was reacted analogously as described in example 4, step 2. Dissolution of the obtained solid in a small quantity of MOH, addition of hydrochloric acid (0.1 M) and lyophilization overnight yielded 12 mg of the title compound in the form of the [7-ethyl-2-(5-fluoro-2-methyl-phenoxy)-1-phenyl-1H-pyrrolo[2,3-c]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

Workup

  1. dissolutionDissolution of the obtained solid

Sources & evidence

ORD record
ord-a3af2ffbd9524a138e6f7084d7ca2434
Source dataset
uspto-grants-2013_11
Patent number
US08580813B2

Reaction notes

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