Hydrochloric Acid → HCID 56672057, compound

HRID 2039863Notes

Reaction equation

HRID 2039863 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:20]3=[N:21][CH:22]=[C:23]([CH3:25])[CH:24]=[C:19]3[N:18]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:17]=2[O:32][C:33]2[CH:38]=[C:37]([F:39])[CH:36]=[CH:35][C:34]=2[CH3:40])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.Cl.Cl.FC1C=CC(C)=C(C=1)OC1N(C2C=CC=CC=2)C2C(=NC=C(C)C=2)C=1C(N1CCNCC1)=O>>[F:39][C:37]1[CH:36]=[CH:35][C:34]([CH3:40])=[C:33]([CH:38]=1)[O:32][C:17]1[N:18]([C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:19]2[C:20](=[N:21][CH:22]=[C:23]([CH3:25])[CH:24]=2)[C:16]=1[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 66922340HCID 66922340, compoundHCID 66922358HCID 66922358, compound

Product 1

HCID 56672057HCID 56672057, compoundYield 15.4%

Procedure

The compound of step 3 (19 mg, 35 μmol) was reacted analogously as described in example 1, step 7. Dissolution of the obtained solid in a small quantity of MOH, addition of hydrochloric acid (0.1 M) and lyophilization overnight yielded 2.4 mg of the title compound in the form of the [2-(5-fluoro-2-methyl-phenoxy)-6-methyl-1-phenyl-1H-pyrrolo[3,2-b]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

Workup

  1. dissolutionDissolution of the obtained solid

Sources & evidence

ORD record
ord-3640038e8cf5413c9a1e18faef4c2691
Source dataset
uspto-grants-2013_11
Patent number
US08580813B2

Reaction notes

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