Hydrochloric Acid → HCID 56678781, compound

HRID 2039864Notes

Reaction equation

HRID 2039864 reaction equation
C(OC(N1CCN(C(C2C3=NC=CC=C3N(C3CCCCC3)C=2Cl)=O)CC1)=O)(C)(C)C.CC1C=CC=C(C)C=1O.Cl.Cl.Cl.[CH:44]1([N:50]2[C:58]3[C:53](=[N:54][CH:55]=[CH:56][CH:57]=3)[C:52]([C:59]([N:61]3[CH2:66][CH2:65][NH:64][CH2:63][CH2:62]3)=[O:60])=[C:51]2[O:67][C:68]2[C:73]([CH3:74])=[CH:72][CH:71]=[CH:70][C:69]=2[CH3:75])[CH2:49][CH2:48][CH2:47][CH2:46][CH2:45]1>>[CH:44]1([N:50]2[C:58]3[C:53](=[N:54][CH:55]=[CH:56][CH:57]=3)[C:52]([C:59]([N:61]3[CH2:62][CH2:63][NH:64][CH2:65][CH2:66]3)=[O:60])=[C:51]2[O:67][C:68]2[C:73]([CH3:74])=[CH:72][CH:71]=[CH:70][C:69]=2[CH3:75])[CH2:49][CH2:48][CH2:47][CH2:46][CH2:45]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 113352,6-DimethylphenolHCID 66922147HCID 66922147, compoundHCID 66922243HCID 66922243, compound

Product 1

HCID 56678781HCID 56678781, compound

Procedure

The compound of step 7 (200 mg, 447 μmol) and 2,6-dimethylphenol were reacted analogously as described in example 1, step 6, and the product subsequently reacted as described in example 1, step 7. The obtained solid was dissolved in a small quantity of MOH, mixed with hydrochloric acid (0.1 M) and lyophilized overnight to give 32 mg of the title compound in the form of the [1-cyclohexyl-2-(2,6-dimethyl-phenoxy)-1H-pyrrolo[3,2-b]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

Workup

  1. customthe product subsequently reacted
  2. dissolutionThe obtained solid was dissolved in a small quantity of MOH

Sources & evidence

ORD record
ord-cb6cc6585fa140678c7f99c932eed8c2
Source dataset
uspto-grants-2013_11
Patent number
US08580813B2

Reaction notes

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