Hydrochloric Acid → HCID 56665121, compound

HRID 2039867Notes

Reaction equation

HRID 2039867 reaction equation
C(OC(N1CCN(C(C2C3=NC=C(OCC)C=C3N(C3C=CC=CC=3)C=2Cl)=O)CC1)=O)(C)(C)C.CC1C=CC=C(C)C=1O.Cl.Cl.Cl.[CH3:47][C:48]1[CH:80]=[CH:79][CH:78]=[C:77]([CH3:81])[C:49]=1[O:50][C:51]1[N:59]([C:60]2[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=2)[C:58]2[C:53](=[N:54][CH:55]=[C:56]([O:66][CH2:67][CH3:68])[CH:57]=2)[C:52]=1[C:69]([N:71]1[CH2:76][CH2:75][NH:74][CH2:73][CH2:72]1)=[O:70]>>[CH3:47][C:48]1[CH:80]=[CH:79][CH:78]=[C:77]([CH3:81])[C:49]=1[O:50][C:51]1[N:59]([C:60]2[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=2)[C:58]2[C:53](=[N:54][CH:55]=[C:56]([O:66][CH2:67][CH3:68])[CH:57]=2)[C:52]=1[C:69]([N:71]1[CH2:72][CH2:73][NH:74][CH2:75][CH2:76]1)=[O:70]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 113352,6-DimethylphenolHCID 66922105HCID 66922105, compoundHCID 66922346HCID 66922346, compound

Product 1

HCID 56665121HCID 56665121, compound

Procedure

The compound of step 7 (28 mg, 57.7 μmol) and 2,6-dimethylphenol were reacted analogously as described in example 1, step 6, and the product subsequently reacted as described in example 1, step 7. The obtained solid was dissolved in a small quantity of MOH, mixed with hydrochloric acid (0.1 M) and lyophilized overnight to give 15 mg of the title compound in the form of the [2-(2,6-dimethyl-phenoxy)-6-ethoxy-1-phenyl-1H-pyrrolo[3,2-b]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

Workup

  1. customthe product subsequently reacted
  2. dissolutionThe obtained solid was dissolved in a small quantity of MOH

Sources & evidence

ORD record
ord-39dc75013ba14ef28ccbcc87f5250bc7
Source dataset
uspto-grants-2013_11
Patent number
US08580813B2

Reaction notes

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