Hydrochloric Acid → HCID 56672056, compound

HRID 2039873Notes

Reaction equation

HRID 2039873 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:20]3=[N:21][CH:22]=[CH:23][CH:24]=[C:19]3[N:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:17]=2[O:31][C:32]2[C:37]([CH3:38])=[CH:36][CH:35]=[CH:34][C:33]=2[CH3:39])=[O:15])[CH2:10][CH:9]1[CH2:40][C:41](=[O:44])[NH:42][CH3:43])=O)(C)(C)C.Cl.Cl.Cl.CC1C=CC=C(C)C=1OC1N(C2C=CC=CC=2)C2C(=NC=CC=2)C=1C(N1CCNC(CC(NC)=O)C1)=O>>[CH3:39][C:33]1[CH:34]=[CH:35][CH:36]=[C:37]([CH3:38])[C:32]=1[O:31][C:17]1[N:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[C:20](=[N:21][CH:22]=[CH:23][CH:24]=2)[C:16]=1[C:14]([N:11]1[CH2:12][CH2:13][NH:8][CH:9]([CH2:40][C:41]([NH:42][CH3:43])=[O:44])[CH2:10]1)=[O:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 66922143HCID 66922143, compoundHCID 66922322HCID 66922322, compound

Product 1

HCID 56672056HCID 56672056, compound

Procedure

The crude compound of step 1 was reacted analogously as described in example 1, step 7, the obtained product dissolved in a small quantity of MOH, mixed with hydrochloric acid (0.1 M) and lyophilized overnight to give 27.6 mg of the title compound in the form of the 2-{4-[2-(2,6-dimethyl-phenoxy)-1-phenyl-1H-pyrrolo[3,2-b]pyridine-3-carbonyl]-piperazin-2-yl}-N-methyl-acetamide dihydrochloride.

Workup

  1. dissolutionthe obtained product dissolved in a small quantity of MOH

Sources & evidence

ORD record
ord-679a5ca94290433eacddd130905ee9af
Source dataset
uspto-grants-2013_11
Patent number
US08580813B2

Reaction notes

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