反应详情

温度

150 °C

To a mixture of 4-fluoro-benzaldehyde (1.5 g, 12.08 mmol) and 2-isopropyl-phenol (1.64 g, 12.08 mmol) in anhydrous N,N-dimethyl acetamide (20 mL) was added granulated potassium carbonate (3.7 g, 26.58 mmol). The reaction mixture was stirred at 150° C. for 18 hours and was partitioned between ethyl acetate and brine. The ethyl acetate layer was washed with saturated aqueous hydrogenocarbonate solution, brine, dried over Na2SO4, filtered, and the solvent evaporated in vacuo to yield a crude oil. The crude oil was purified via flash chromatography (15% ethyl acetate in n-heptane) to yield 4-(2-Isopropyl-phenoxy)-benzaldehyde as a gum (2.25 g, 77%).

1. customwas partitioned between ethyl acetate and brine
2. washThe ethyl acetate layer was washed with saturated aqueous hydrogenocarbonate solution, brine
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. customthe solvent evaporated in vacuo
6. customto yield a crude oil
7. customThe crude oil was purified via flash chromatography (15% ethyl acetate in n-heptane)