Water → 5-[4-(2-Isopropyl-phenoxy)-benzylidene]-2-methylsulfanyl-thiazol-4-one

HRID 2040112노트

반응식

HRID 2040112 반응식
[CH:1]([C:4]1[CH:24]=[CH:23][CH:22]=[CH:21][C:5]=1[O:6][C:7]1[CH:20]=[CH:19][C:10]([CH:11]=[C:12]2[S:16][C:15](=[S:17])[NH:14][C:13]2=[O:18])=[CH:9][CH:8]=1)([CH3:3])[CH3:2].CI.[CH:27](N(C(C)C)CC)(C)C.O>C(O)C>[CH:1]([C:4]1[CH:24]=[CH:23][CH:22]=[CH:21][C:5]=1[O:6][C:7]1[CH:20]=[CH:19][C:10]([CH:11]=[C:12]2[S:16][C:15]([S:17][CH3:27])=[N:14][C:13]2=[O:18])=[CH:9][CH:8]=1)([CH3:3])[CH3:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 81531DiisopropylethylamineHCID 866231455-[4-(2-Isopropyl-phenoxy)-benzylidene]-2-thioxo-thiazolidin-4-one

생성물 1

HCID 690899295-[4-(2-Isopropyl-phenoxy)-benzylidene]-2-methylsulfanyl-thiazol-4-one수율 101.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 5-[4-(2-Isopropyl-phenoxy)-benzylidene]-2-thioxo-thiazolidin-4-one (0.4 g, 1.12 mmol) in Ethanol (14 mL) was added CH3I (0.32 g, 2.25 mmol) and diisopropylethylamine (0.17 g, 1.35 mmol). The reaction mixture was stirred at room temperature for 4 h. It was then added water (40 mL) and the slurry was stirred at room temperature for 30 minutes. The solid was filtered, washed with water to yield the 5-[4-(2-Isopropyl-phenoxy)-benzylidene]-2-methylsulfanyl-thiazol-4-one as a yellow solid (0.42 g, 94%)

후처리

  1. filtrationThe solid was filtered
  2. washwashed with water

출처 및 근거

ORD 기록
ord-e1e78565f58b45a1a50e2094fbf2e5bf
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580832B2

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