Chlorosuccinimide → HCID 67169326, compound

HRID 2040337Notes

Reaction equation

HRID 2040337 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][N:8]2[C:12]3=[N:13][CH:14]=[C:15]([S:17]([NH2:20])(=[O:19])=[O:18])[CH:16]=[C:11]3[CH:10]=[CH:9]2)[CH2:3][CH2:2]1.[Cl:21]N1C(=O)CCC1=O>CC#N>[Cl:21][C:10]1[C:11]2[C:12](=[N:13][CH:14]=[C:15]([S:17]([NH2:20])(=[O:18])=[O:19])[CH:16]=2)[N:8]([CH2:7][CH:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)[CH:9]=1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 67127242HCID 67127242, compound

Product 1

HCID 67169326HCID 67169326, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of EXAMPLE 388C (0.15 g) and N-chlorosuccinimide (0.081 g) in CH3CN (8 mL) was heated at 90° C. for 16 hours. The solvent was removed, and the residue was purified by flash column chromatography on silica to give the title compound.

Workup

  1. customThe solvent was removed
  2. customthe residue was purified by flash column chromatography on silica

Sources & evidence

ORD record
ord-501b2a4e78414fda8e95c78bec89897d
Source dataset
uspto-grants-2013_11
Patent number
US08580794B2

Reaction notes

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