1-Butanaminium, N,N,N-tributyl-, fluoride, hydrate → HCID 57493850, compound

HRID 2040878Notes

Reaction equation

HRID 2040878 reaction equation
C[Si](C)(C)[C:3]#[C:4][C:5]1[CH2:19][C:8]2([CH2:11][N:10]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:9]2)[O:7][N:6]=1.O.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[C:4]([C:5]1[CH2:19][C:8]2([CH2:11][N:10]([C:12]([O:14][C:15]([CH3:17])([CH3:16])[CH3:18])=[O:13])[CH2:9]2)[O:7][N:6]=1)#[CH:3]

Participants

4

Reactant 2

HCID 162116731-Butanaminium, N,N,N-tributyl-, fluoride, hydrateHCID 57493823HCID 57493823, compound

Product 1

HCID 57493850HCID 57493850, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of Compound 28b (557 mg, 1.81 mmol) and tetrabutylammonium fluoride hydrate (759 mg, 2.72 mmol) in 10 mL of THF was stirred at r.t. for 4 h. After the usual work-up with EtOAc-water the crude residue was used in the next step without further purification.

Workup

  1. customAfter the usual work-up with EtOAc-water the crude residue was used in the next step without further purification

Sources & evidence

ORD record
ord-b5e16263c1dd4dd2a08d7d9c931ad0c5
Source dataset
uspto-grants-2013_11
Patent number
US08580962B2

Reaction notes

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