反应详情

Add triflic anhydride (1.28 mL, 2.14 g) dropwise to a stirred solution of 2,2-difluoro-2-phenyl-ethanol (0.8 g, 5.06 mmol) and 2,6-di-tert-butyl-4-methylpyridine (1.556 g, 7.59 mmol) in anhydrous dichloromethane (25 mL) at −78° C. Stir the reaction overnight while the temperature warms up. Dilute the mixture with pentane and filter the precipitate over Celite®. Concentrate the filtrate in vacuo and purify the crude mixture by chromatography on silica gel eluting with hexane and hexane/EtOAc (95:5) to provide the title compound (946 mg, 64%).

1. customthe reaction overnight while the temperature
2. filtrationfilter the precipitate over Celite®
3. concentrationConcentrate the filtrate in vacuo
4. custompurify the crude mixture by chromatography on silica gel eluting with hexane and hexane/EtOAc (95:5)