反应详情

温度

-10 °C

Dissolve 4-(3,3-dimethyl-butyryl)-benzaldehyde (1.67 g, 8.186 mmol) in anhydrous THF (20 mL) and cool the solution at −10° C. Add methyl magnesium bromide (2.7 mL, 8.186 mmol, 3M solution in diethyl ether) and stir the mixture for 30 min. Add water at 0° C., dilute with EtOAc and extract the aqueous layer three times with EtOAc. Dry the combined organic extracts over Na2SO4, filter through a short pad of silica gel and concentrate in vacuo to .give the desired intermediate as yellow oil (1.519 g, 84%).

1. extractionextract the aqueous layer three times with EtOAc
2. dry with materialDry the combined organic extracts over Na2SO4
3. filtrationfilter through a short pad of silica gel
4. concentrationconcentrate in vacuo