HRID20416

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@H]1[C@H](OCC(C)(C)C)OC[C@H]([C@@H](OCc2ccccc2)[C@H](Cc2cc(F)cc(F)c2)N(Cc2ccccc2)Cc2ccccc2)N1C(=O)OC(C)(C)C

HCID68562066

未命名化合物

PRODUCTS

生成物

结构：C[C@H]1[C@H](OCC(C)(C)C)OC[C@H]([C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)N1C(=O)OC(C)(C)C

HCID68561942

未命名化合物

收率 97.3%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID9942167

Palladium hydroxide

H2O2Pd

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Stir (2R,3S,5R)-5-[(1S,2S)-1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-(2,2-dimethylpropoxy)-3-methylmorpholine-4-carboxylic acid tert-butyl ester (645 mg, 0.87 mmol) and 20% palladium hydroxide on carbon (60% moisture, 645 mg) in ethyl acetate (10 mL) under one-atmosphere of hydrogen gas at room temperature overnight. Filter the suspension through a pad of filtering agent, wash with ethyl acetate and concentrate to give the desired compound (400 mg, 97%).

WORKUP

后处理

filtrationFilter the suspension through a pad
filtrationof filtering agent
washwash with ethyl acetate
concentrationconcentrate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e3f9ed12ef2c464aae73ca7c67894b7e
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07745438B2
来源说明: uspto-grants-2010_06

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[C@@H:13]([C@@H:14]([O:40]CC2C=CC=CC=2)[C@@H:15]([N:25](CC2C=CC=CC=2)CC2C=CC=CC=2)[CH2:16][C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([F:24])[CH:18]=2)[CH2:12][O:11][C@@H:10]([O:48][CH2:49][C:50]([CH3:53])([CH3:52])[CH3:51])[C@@H:9]1[CH3:54])=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(OCC)(=O)C.[OH-].[OH-].[Pd+2]>[C:1]([O:5][C:6]([N:8]1[C@@H:13]([C@@H:14]([OH:40])[C@@H:15]([NH2:25])[CH2:16][C:17]2[CH:18]=[C:19]([F:24])[CH:20]=[C:21]([F:23])[CH:22]=2)[CH2:12][O:11][C@@H:10]([O:48][CH2:49][C:50]([CH3:53])([CH3:52])[CH3:51])[C@@H:9]1[CH3:54])=[O:7])([CH3:2])([CH3:4])[CH3:3]