Triethylamine → HCID 68432550, compound

HRID 2041947Notes

Reaction equation

HRID 2041947 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=1)[C:6]([C:19](O)=[O:20])=[CH:5]2.Cl.[N:23]1([C:28]2[N:33]=[CH:32][C:31]([NH2:34])=[C:30]([C:35]([F:38])([F:37])[F:36])[CH:29]=2)[CH2:27][CH2:26][CH2:25][CH2:24]1.C(N(CC)CC)C>>[N:23]1([C:28]2[N:33]=[CH:32][C:31]([NH:34][C:19]([C:6]3[N:7]([CH2:11][C:12]4[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=4)[C:8]4[C:4]([CH:5]=3)=[CH:3][C:2]([F:1])=[CH:10][CH:9]=4)=[O:20])=[C:30]([C:35]([F:38])([F:36])[F:37])[CH:29]=2)[CH2:27][CH2:26][CH2:25][CH2:24]1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 574315135-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acidHCID 57431528HCID 57431528, compound

Product 1

HCID 68432550HCID 68432550, compound

Procedure

The process is carried out according to the method described in step 5.3, using 0.3 g (1.04 mmol) of 5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid (example 1.1), and of 0.363 g (1.36 mmol) of 6-(pyrrolidin-1-yl)-4-trifluoromethyl-3-aminopyridine hydrochloride, prepared in step 11.4, in the presence of 0.22 ml (1.57 mmol) of triethylamine.

Sources & evidence

ORD record
ord-a4e850abe702474399aaa023809716f7
Source dataset
uspto-grants-2013_11
Patent number
US08586573B2

Reaction notes

Loading…