Potassium Carbonate → HCID 58316701, compound

HRID 2042185Notes

Reaction equation

HRID 2042185 reaction equation
[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([CH3:18])([CH3:17])[CH2:12][O:13]C(=O)C)[N:10]=2)[CH:7]=1.C([O-])([O-])=O.[K+].[K+]>CO>[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([CH3:18])([CH3:17])[CH2:12][OH:13])[N:10]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 58316711HCID 58316711, compound

Product 1

HCID 58316701HCID 58316701, compoundYield 99.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of acetic acid 2-(6-iodo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-2-methyl-propyl ester (example 40, step 6) (750 mg, 2.09 mmol) and K2CO3 (576 mg, 4.18 mmol, 2 equiv.) in MeOH (8 ml) was stirred at 25° C. for 2 hours. The solvent was evaporated and the resulting crude product was purified by column chromatography. The desired 2-(6-iodo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-2-methyl-propan-1-ol (662 mg, 91% yield) was obtained as a white solid, MS: m/e=318.0 (M+H+).

Workup

  1. customThe solvent was evaporated
  2. customthe resulting crude product was purified by column chromatography

Sources & evidence

ORD record
ord-5bea4ca3e986445988a7ffde07bf6784
Source dataset
uspto-grants-2013_11
Patent number
US08586581B2

Reaction notes

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