4-Chlorobenzoic Acid → HCID 178523699, compound

HRID 2042443Notes

Reaction equation

HRID 2042443 reaction equation
Cl.Cl.Cl.[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1.[Cl:28][C:29]1[CH:37]=[CH:36][C:32]([C:33](O)=[O:34])=[CH:31][CH:30]=1>>[Cl:28][C:29]1[CH:37]=[CH:36][C:32]([C:33]([NH:27][C@H:24]2[CH2:25][CH2:26][C@H:21]([CH2:20][CH2:19][N:16]3[CH2:17][CH2:18][N:13]([C:8]4[C:7]5[CH2:6][CH2:5][O:4][C:12]=5[CH:11]=[CH:10][N:9]=4)[CH2:14][CH2:15]3)[CH2:22][CH2:23]2)=[O:34])=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 63184-Chlorobenzoic AcidHCID 178478589HCID 178478589, compound2×

Product 1

HCID 178523699HCID 178523699, compound

Procedure

The title compound, off-white solid (103 mg, 88%), MS (ISP) m/z=469.3 [(M+H)+], mp 226.5° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (110 mg, 0.25 mmol) and 4-chlorobenzoic acid.

Sources & evidence

ORD record
ord-0bd5e31b7e4d4b2ba2d993ddd1f34546
Source dataset
uspto-grants-2013_11
Patent number
US08586579B2

Reaction notes

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