1-Bromo-3-chloropropane → HCID 59651896, compound

HRID 2042541Notes

Reaction equation

HRID 2042541 reaction equation
BrCCCCl.[Cl:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:18]=[C:19]([CH3:25])[C:20](=[O:24])[N:21]([CH3:23])[N:22]=2)=[CH:13][CH:12]=1.[NH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>>[Cl:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:12]=[CH:13][C:14]([C:17]2[CH:18]=[C:19]([CH3:25])[C:20](=[O:24])[N:21]([CH3:23])[N:22]=2)=[CH:15][CH:16]=1.[CH3:23][N:21]1[C:20](=[O:24])[C:19]([CH3:25])=[CH:18][C:17]([C:14]2[CH:15]=[CH:16][C:11]([O:10][CH2:9][CH2:8][CH2:7][N:26]3[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]3)=[CH:12][CH:13]=2)=[N:22]1

Participants

5

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 8082PiperidineHCID 67009916HCID 67009916, compound

Product 2

HCID 59651896HCID 59651896, compoundHCID 67009916HCID 67009916, compound

Procedure

6-(4-(3-Chloropropoxy)-phenyl)-2,4-dimethyl-2H-pyridazin-3-one was prepared from the product of step 3 and 3-bromo-1-chloropropane using the procedure described for Example 22 step 4. Example 39 (2,4-dimethyl-6-[4-(3-piperidin-1-yl-propoxy)-phenyl]-2H-pyridazin-3-one) was prepared using 6-(4-(3-chloropropoxy)-phenyl)-2,4-dimethyl-2H-pyridazin-3-one and piperidine by the methods described for example 22 step 5. The hydrochloride salt was prepared; Mp 222-3° C.; MS m/z 342 (M+H).

Sources & evidence

ORD record
ord-aea1fafc42a9495a8634482cbb83f56a
Source dataset
uspto-grants-2013_11
Patent number
US08586588B2

Reaction notes

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