反应详情

In a 500 mL round bottom flask, 4-[4-(3-chloro-propoxy)-phenyl]-4-oxo-butyric acid ethyl ester (7.85 g, 26.3 mmol), and hydrazine monohydrate (2.55 mL, 52.7 mmol), in isopropanol (200 mL) was heated to reflux 14 h. The reaction was cooled and the solvent concentrated under vacuum. Purification with silica gel chromatography eluting with methylene chloride/methanol (95:5) produced 5.2 g (74%). MS m/z 267 (M+H).

1. temperatureto reflux 14 h
2. temperatureThe reaction was cooled
3. concentrationthe solvent concentrated under vacuum
4. customPurification with silica gel chromatography
5. washeluting with methylene chloride/methanol (95:5)
6. customproduced 5.2 g (74%)