HCID 59652050, compound → HCID 59652065, compound

HRID 2042648Notes

Reaction equation

HRID 2042648 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH2:26][CH2:25][C:24](=[O:27])[NH:23][N:22]=3)=[C:17]([F:28])[CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[F:28][C:17]1[CH:16]=[C:15]([O:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:20]=[CH:19][C:18]=1[C:21]1[CH2:26][CH2:25][C:24](=[O:27])[NH:23][N:22]=1

Participants

3

Reactant 1

HCID 59652050HCID 59652050, compound

Product 1

HCID 59652065HCID 59652065, compoundYield 144.2%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

In a 10 mL round bottom flask, 4-[3-fluoro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester (410 mg, 1.0 mmol) in trifluoroacetic acid (3 mL) was stirred 2 h. The solvent concentrated under vacuum to produce 420 mg (100%) of the salt as an oil. MS m/z=292 (M+H).

Workup

  1. concentrationThe solvent concentrated under vacuum

Sources & evidence

ORD record
ord-163af5966fcd44ffb5fa8bad002c37e9
Source dataset
uspto-grants-2013_11
Patent number
US08586588B2

Reaction notes

Loading…