Ammonium Hydroxide → HCID 178471768, compound

HRID 2042723Notes

Reaction equation

HRID 2042723 reaction equation
[OH-].[NH4+:2].Cl[C:4]([C:6]1[CH:11]=[CH:10][C:9]([C@H:12]2[CH2:17][CH2:16][C@H:15]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:14][CH2:13]2)=[CH:8][CH:7]=1)=[O:5]>>[C:4]([C:6]1[CH:11]=[CH:10][C:9]([C@H:12]2[CH2:17][CH2:16][C@H:15]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:14][CH2:13]2)=[CH:8][CH:7]=1)(=[O:5])[NH2:2]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 178471771HCID 178471771, compound

Product 1

HCID 178471768HCID 178471768, compoundYield 100%

Procedure

Ammonium hydroxide (large excess) was added to the product from Example 1C (8.43 g. 27.3 mmol) at room temperature. White solids precipitated out and were collected by filtration and washed with water to afford the title compound (7.9 g, 100%) as a white solid which was taken on to the next step-without further purification. MS (DCI) m/z 290.1 [M+H]+.

Workup

  1. customWhite solids precipitated out
  2. filtrationwere collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-4f6167a20fe34dc197af82a6051e73a4
Source dataset
uspto-grants-2013_11
Patent number
US08586594B2

Reaction notes

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